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About the test
What is this test done for?
Apolipoprotein B (APO B) is a rare blood test done to evaluate the risk of developing cardiovascular disease and for monitoring treatment for high cholesterol.
Why is it Done?
Apolipoprotein B is a protein involved in metabolism of the lipids. The test is performed along with the lipid profile to evaluate the risk of developing a heart disease, though not done as a screening test. It is mainly done if there is strong past or family history of heart disease or risk factors for heart disease like diabetes, high blood pressure, etc.
When should it be performed?
This test is done along with other tests like apolipoprotein A-1, lipid profile so as to evaluate the risk of developing cardiovascular disease:
  • One has history of abnormal lipids especially triglycerides.
  • Family history of abnormal lipids.
  • History of premature cardiovascular diseases in past or in the family.
  • To determine the cause of abnormal lipid profile.
  • To help diagnose a genetic problem that causes over or under production of Apo B
How is it done
A blood sample will be collected from a vein in your arm. The test is done after 12 hours of fasting.
The following can help to assess:
  • High risk: CHD or CHD risk equivalent
    • ApoB < 90 mg/dL / LDL-C< 100 mg/dL
  • Moderate risk: ≥ 2 risk factors
    • ApoB < 110 mg/dL / LDL-C < 130 mg/dL
  • Low risk: 0-1 risk factors
    • ApoB < 130 mg/dL / LDL-C < 160 mg/dL
Abnormal levels of Apo- b are seen in:
  • Diabetes
  • Use of certain medications like androgens, beta blockers etc.
  • Hypothyroidism
  • Nephrotic syndrome
  • Pregnancy (temporary)
Apo-B may decrease with:
  • Physical exercise.
  • Weight reduction
  • Malnourishment
  • Severe illness
  • Reye syndrome
  • Use of certain medications like statins, estrogens, oral contraceptives.
High ratio of Apo A-1 and Apo B are associated with the risk of cardiovascular disease.
Other Tests
Lipid profile is done in order to get the values of trigycerides and then co-relate with the risk of the person. Apolipoprotein A-1 is also performed to help confirm diagnosis.
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