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APOLIPOPROTEIN A-1

About the test
What is this test done for?
Apolipoprotein A-1 (APO A-1) is a vital protein that makes 70% of high density lipoprotein (HDL) cholesterol in our body. The test determines its blood levels to assess risk of heart disease.
Why is it Done?
It is done to determine whether or not one has adequate level APO A-1 especially when one has low level of HDL to determine the risk of developing cardiovascular disease.
When should it be performed?
This test is done when:
  • One has history of abnormal lipid profile.
  • Family history of abnormal lipids.
  • History of premature cardiovascular diseases in past or in the family.
  • To determine the cause of high cholesterol
  • It is done with other tests and Apo B to get the ratio and detect bad versus good cholesterol.
How is it done
A blood sample will be collected from a vein in your arm. The test is done after 12 hours of fasting.
Results
Reference range is as follows: Men- abnormal if greater than 120mg/dL Women- abnormal if greater than 140mg/dL. Apo A-1 may decrease with:
  • Chronic kidney disease
  • Use of certain medications like androgens, beta- blockers
  • Smoking
  • Uncontrolled diabetes
  • Obesity.
Apo A-1 may increase with:
  • Physical exercise.
  • Weight reduction
  • Use of statins (lipid lowering drugs)
  • Use of certain medications like estrogens, oral contraceptives, Phenobarbital.
Low Apo A-1 and high Apo B are associated with the risk of cardiovascular disease.
Other Tests
Lipid profile is done in order to get the values of HDL and then correlate to assess the risk of the person. Apolipoprotein B is also performed to help assess risk.
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