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ANTI PHOSPHOLIPID IGM

About the test
What is this test done for?
Antiphospholipid IgM or antiphospholipid antibody is a blood test done for detecting presence of antibodies against plasma proteins present in the blood.
Why is it Done?
This is a specialized test done for diagnosing antiphospholipid syndrome. Anticardiolipin antibodies found in blood help in determining the cause of
  • Inappropriate and Unexplained blood clot formation, inside an artery or vein (thrombotic episode)
  • Prolonged PTT or increased PT(INR)
  • Recurrent miscarriages
  • Unexplained low platelet count
When should it be performed?
This test is performed
  • If a patient has signs and symptoms of antiphospholipid syndrome
    • Abnormal or unexplained clot formation in the body
    • Platelet deficiency or low platelet counts
    • Presence of one or more antiphospholipid or anticardiolipin antibodies
  • If a patient presents with signs and symptoms of a blood clot in an intact artery or vein (thrombotic episode); signs and symptoms vary as per the location of the blood clot
    • If it is in leg (DVT or deep vein thrombosis)
      • Severe leg pain, usually of one leg
      • Swelling of the affected leg
      • Purplish or bluish discoloration of the affected leg
    • If it is in lungs (pulmonary embolism)
      • Shortness of breath, which is sudden onset
      • Difficulty in breathing, labored breathing
      • Cough with bloody sputum
      • Increased heart rate
      • Lung-related chest pain
  • If a female complaints of repeated miscarriages ( above 10 weeks of pregnancy) and has abnormal PTT or PT (INR)
  • If a patient has autoimmune disorders like rheumatoid arthritis, systemic lupus erythematosus etc
  • If a patient experiences repeated thrombotic episodes like stroke or heart attack
  • If a patient has unexplained low platelet counts and hemolytic anemia
How is it done
Venous blood sample is collected from vein at any time of the day, without any fasting.
Results
Negative, if levels are below 10 MPL units/mL
  • Absence of antiphospholipid syndrome
  • Very low or negligible risk of thrombotic episodes
Positive, if levels are above 10 MPL units/mL
  • Antiphospholipid syndrome
  • High risk of thrombotic episodes
  • Certain Cancers
  • Autoimmune disorders
Other Tests
  • Cardiolipin IgG
    • Positive results indicate antiphospholipid syndrome
  • Cardiolipin IgM
    • Positive results indicate antiphospholipid syndrome
  • aPTT
    • Increased time indicate bleeding disorders
  • Lupus anticoagulant testing
    • Positive results indicate abnormal clotting
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