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About the test
What is this test done for?
Anti TPO antibodies is a blood test done for detecting antibodies present in the blood against the thyroid gland.
Why is it Done?
This is a specialized test done for detecting the cause of thyroid disease. Presence of these antibodies suggests that the cause is an autoimmune disease like Hashimoto’s thyroiditis, Grave’s disease or idiopathic myxedema.
When should it be performed?
This test is performed when a patient presents with symptoms of hypothyroidism, which includesThis test is performed when a patient presents with symptoms of hypothyroidism, which includes
  • Easy fatigability
  • Constipation
  • Increased sensitivity to cold
  • Weight gain
  • Puffy face
  • Dry skin
  • Muscle weakness
  • Pain, stiffness & swelling of joints
  • Irregular menstrual periods
  • Thinning of hair
  • High levels of cholesterol in blood
  • Slow heart rate
  • Impaired memory or depression
This test is even performed in patients with subclinical hypothyroidism or with marginal elevation of TSH levels without any changes in T3 or T4 levels.
How is it done
A blood sample will be collected from a vein in your arm. Fasting is not needed. Avoid use of multivitamins or dietary supplements having Biotin or Vitamin B7 for about 12 hours before the test.
  • The test is negative if levels are < 9 IU/mL and means absence of autoimmune thyroid disorder.
  • The test is Positive if levels are > 9 IU/mL and means presence of auto immune cause of hypothyroidism like Hashimoto’s thyroiditis, idiopathic myxedema or Grave’s disease
  • Some people have raised Anti TPO antibodies without any thyroid dysfunction. However, this makes them prone to develop thyroid disease in future. Thus in such people this test is done periodically along with thyroid function test to keep a check on future thyroid problems.
Other Tests
  • TRAb
    • This is a specific test for ruling out Grave’s disease
  • Thyroglobulin antibodies
    • This test is done for checking antibodies against thyroglobulin
    • It indicates the cause of thyroid disease as Hashimoto’s thyroiditis or idiopathic myxedema
  • Anti Na+/I– symporter antibodies
    • This test is done for confirming the cause of thyroid disease
    • It is positive if the patient has autoimmune thyroiditis
  • T3, T4 & TSH
    • This is a thyroid function test, which evaluates levels of TSH hormone along with T3 & T4 hormones in the blood
    • High levels of TSH and low levels or T3 or T4 suggest hypothyroidism
  • Free T3, Free T4 and TSH
    • This is also a thyroid function test, in which active T3 & T4 levels (not bound to globulin) are measured along with TSH levels
    • Low Free T3 & T4 levels along with High TSH levels indicate presence of hypothyroidism
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