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ASMA (Anti-Smooth-Muscle-Antibody)

About the test
What is this test done for?
Anti Smooth Muscle antibody (ASMA) test is done to detect the antibodies in the serum of the patients with chronic liver disease.
Why is it Done?
It is done –
  • To evaluate causes for hepatitis
  • To determine liver inflammation is autoimmune or not
  • To diagnose autoimmune hepatitis
When should it be performed?
It should be performed when the patients present with liver disease suspected to have underlying autoimmune cause clinically presenting as
  • Acute hepatitis
  • Chronic hepatitis
  • Liver cirrhosis
  • Hepatic failure
  • Asymptomatic patient with elevated levels of liver enzymes.
How is it done
A blood sample will be collected from a vein in your arm. Fasting is not required prior to sample collection.
  • Normal values – Negative titre (healthy individual)
  • Positive values – 1 : 40 underlying condition autoimmune hepatitis type 1
  • Strongly positive - above 1 : 80 infection with hepatitis B, C, primary biliary cirrhosis.
Other Tests
Immunoglobulin levels, ANA test (Antinuclear Antibody), Antiliver microsomal antibody, (Anti-LKM), Liver cytosol Antibody type (Anti-LC1). These tests can be done to confirm origin of hepatitis. Liver function tests should be done to monitor hepatitis status.
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