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About the test
What is this test done for?
The anti-Saccharomyces cerevisiae antibodies (ASCA)IgA test is for distinguishing between ulcerative colitis (UC) and Crohn’s disease (CD) which are types of inflammatory bowel diseases (IBD).
Why is it Done?
ASCA are immune proteins that are present in people in IBD. The presence of ASCA is more common in patients having Crohn’s disease and thus helps confirm that it is CD and not UC.
When should it be performed?
Signs and symptoms that suggest IBD are as follows:
  • Abdominal cramps and pain
  • Diarrhoea
  • Rectal bleeding
  • Fever
  • Fatigue
  • In children, growth retardation.
How is it done
A blood sample will be collected from a vein in your arm. For doing ASCA IgA, fasting is not needed prior to sample collection.
The results of ASCA are always considered along with neutrophil specific antibodies (NSA) or perinuclear anti neutrophil cytoplasmic antibody (pANCA) testing to confirm with the diagnosis.
  • IASCA is positive and NSA is negative, then it suggests CD.
  • If ASCA is negative and NSA is positive, then it would suggest that the person is suffering from UC.
Other Tests
pANCA is an important test to get a clear diagnosis. An ASCA test is often ordered along with a test for perinuclear anti-neutrophil cytoplasmic antibody (pANCA) which helps to determine the type of IBD a person is suffering from. The presence of ASCA is more common in CD, while pANCA is more common in UC.
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