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AMA (ANTI MITOCHONDRIAL ANTIBODY)

About the test
What is this test done for?
Anti-mitochondrial antibody is a blood test done for detecting antibodies present in the blood against mitochondrion antigen present in the cells.
Why is it Done?
This is a specialized test done for diagnosing primary biliary cirrhosis (PBC). Presence of these antibodies suggests that the cause of cirrhosis or liver failure is an autoimmune disease i.e. primary biliary cirrhosis.
When should it be performed?
This test is performed when a patient presents with
  • Jaundice
  • Itching (pruritus)
  • Fatigue
  • Abdominal pain
  • Enlarged liver
  • Swelling over foot
  • Dryness of mouth and eyes
  • A fluid accumulation in abdomen
This test is even performed in patients with abnormal liver function test (increased liver enzymes i.e. SGOT, SGPT and Alkaline Phosphatase along with increased bilirubin levels)
How is it done
A blood sample will be collected from a vein in your arm. No special precautions like fasting are required.
Results
Negative, if levels are below 0.1 Units
  • Absence of primary biliary cirrhosis
Positive, if levels are above 1 Units
  • Primary biliary cirrhosis
Other Tests
  • Liver function Test or Liver profile
  • This is a routine investigation, used for evaluating the functioning of the liver
  • High levels of SGOT/SGPT, Alkaline phosphatase and direct bilirubin may suggest liver injury or cirrhosis
  • ASMA or Anti smooth muscle antibody
  • It is a specialized blood test that evaluates the presence of antibodies against smooth muscles
  • Positive test indicates autoimmune hepatitis
  • ANA or Anti nuclear antibody
  • It is a specialized test that evaluates the presence of antibodies against cells
  • Positive results indicate autoimmunity as a cause of disease
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