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About the test
What is this test done for?
Anti CCP antibody or cyclic citrullinated peptide (CCP) is a blood test done for detecting antibodies present in the blood against cyclic citrullinated peptides.
Why is it Done?
This is a specialized test done for diagnosing rheumatoid arthritis (RA). Presence of these antibodies suggests that the cause of joint pains is an auto immune disease i.e. rheumatoid arthritis.
When should it be performed?
This test is performed when a patient presents with
  • Joint pains affecting multiple joints
    • Most commonly affected joints are joints fingers, wrists and ankles
    • Along with pain joints are swollen and may appear red
  • Stiffness of joints, more in morning/waking hours
  • Joint stiffness lasting for ≥ 1 hour
  • Fatigue
  • Fever
  • Nodules under the skin (especially at the elbows)
  • A generalized feeling of being unwell (malaise)
How is it done
A venous blood sample is collected from a vein in your arm at any time of the day. Fasting is not required.
Negative, if levels are below 20 Units
  • Absence of rheumatoid arthritis
Positive, if levels are above 40 Units
  • Rheumatoid arthritis (Moderate severity)
Strongly positive, if levels are above 60 Units
  • Severe form of rheumatoid arthritis
Other Tests
  • RA factor
  • This is a specialized blood test done for evaluating the presence of RA factor or rheumatoid factor in the blood
  • Positive results indicate rheumatoid arthritis
  • ESR
  • This is a routine blood test that acts as an inflammatory marker
  • Positive test indicates inflammation
  • CRP or C reactive proteins
  • It is a specialized test that evaluates amount of c reactive proteins present in the blood
  • High CRP levels indicate active inflammation
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