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About the test
What is this test done for?
17-OH progesterone is a blood test that measures amount of hormone progesterone produced by the adrenal glands and sex glands.
Why is it Done?
17OH progesterone is a hormone produced by the adrenal glands. This hormone along with certain enzymes helps to produce cortisol which is a hormone involved during stress. If enough cortisol is not produced, then 17 OH progesterone builds up in the body and increased levels indicate condition called congenital adrenal hyperplasia (CAH).
When should it be performed?
The test should be performed as a screening for all new born babies or when the symptoms of CAH are suspected- • Signs and symptoms in an infant include: • Genitals which are not distinguishable • Pubic hair • Acne • Lack of energy • Disinterest in eating • Dehydration • Low blood pressure • vomiting • Signs and symptoms in young girls and adult women are: • Irregular periods • Genitalia that have both male and female feature, more of male characteristics. • Excessive hair growth • Infertility • Signs and symptoms in young boys and adult men: • Early onset of puberty. • Deep voice • Large penis, small testes. • Infertility
How is it done
A blood sample will be collected from a vein in your arm. For doing the test, 8 hours fasting is required prior to collection.
The normal values are: • Newborns- 1000 to 3000ng/dL • Babies older than 24 hours: less than 100 ng/dL. • Adults: less than 200 ng/dL. Higher levels of the test indicate that the person is suffering from CAH and also could suggest presence of adrenal tumor. If a person is on treatment for CAH and if the levels are higher or lower, it suggests altering the doses of treatment is necessary.
Other Tests
In rare cases, the amniotic fluid is tested to diagnose the condition during pregnancy. ACTH is another test to be done for further confirmation.
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