{"id":242933,"date":"2025-06-23T10:49:13","date_gmt":"2025-06-23T10:49:13","guid":{"rendered":"https:\/\/pharmeasy.in\/blog\/?p=242933"},"modified":"2026-03-25T11:01:26","modified_gmt":"2026-03-25T11:01:26","slug":"vaccine-typhoid-vaccine-what-is-it-types-when-to-be-taken-side-effects","status":"publish","type":"post","link":"https:\/\/pharmeasy.in\/blog\/vaccine-typhoid-vaccine-what-is-it-types-when-to-be-taken-side-effects\/","title":{"rendered":"Typhoid Vaccine: What is It, Types, When to Be Taken & Side Effects"},"content":{"rendered":"\n\n<\/head>

Table of Contents<\/p>\nToggle<\/span>

Introduction<\/a><\/li>
What is the Typhoid Vaccine?<\/a><\/li>
Types of Typhoid Vaccines<\/a><\/li>
Why is the Typhoid Vaccine Important?<\/a><\/li>
Who Should Get the Typhoid Vaccine?<\/a><\/li>
Who Should Not Get the Vaccine?<\/a><\/li>
How is the Vaccine Given<\/a><\/li>
When and How Often to Get the Typhoid Shot<\/a><\/li>
Effectiveness and Safety of the Typhoid Vaccine<\/a><\/li>
Possible Side Effects of Typhoid Vaccines<\/a><\/li>
When to See a Doctor<\/a><\/li>
Conclusion<\/a><\/li>
Frequently Asked Questions (FAQs)<\/a><\/li>
References<\/a><\/li><\/ul><\/nav><\/div>\n \n <\/span>\n $\"Join$ \n <\/a>\n
<\/span>Introduction<\/strong><\/span><\/h2>\n\n\n\nTyphoid fever is a serious (and potentially life-threatening) illness caused by the bacterium Salmonella Typhi<\/strong><\/a><\/em> that spreads primarily through contaminated food and water. Once inside the body, the bacteria rapidly multiply in the intestinal lymphoid tissue known as Peyer\u2019s patches, and eventually enter the bloodstream, leading to infection (bacteraemia)^{1<\/sup><\/a>^,<\/sup>}^{2<\/sup><\/a>.\u00a0\u00a0<\/p>\n\n\n\n}
With increasing urbanisation, poor sanitation, and the growing threat of antibiotic-resistant strains, the global risk of typhoid is rising, especially in communities lacking clean water and proper hygiene ^{1<\/sup><\/a>^,<\/sup>}^{2<\/sup><\/a>.\u00a0<\/p>\n\n\n\n}
Given the public health threat posed by typhoid fever, vaccination plays a crucial role in prevention. This article explores the typhoid vaccine, what it is, the types available, when it should be administered, and its possible side effects, helping you make informed decisions about protection against this preventable disease.\u00a0<\/p>\n\n\n\n
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<\/span>What is the Typhoid Vaccine?<\/strong><\/span><\/h2>\n\n\n\nThe typhoid vaccine<\/strong><\/a> is a preventive vaccine that provides immunity against the Salmonella Typhi<\/em> bacterium, which is responsible for causing typhoid fever^{2<\/sup><\/a>^,<\/sup>}^{3<\/sup><\/a>.\u00a0\u00a0<\/p>\n\n\n\n}
The vaccine consists of either weakened live bacteria or inactive (killed) bacteria (alone or attached to a carrier protein). When the body is exposed to the bacteria or its antigens, it helps in developing long-lasting protection by stimulating the immune system to recognise and fight the bacteria if exposed in the future. While the vaccine does not treat active infection, it plays a critical role in preventing illness and reducing its spread ^{3<\/sup><\/a>.\u00a0<\/p>\n\n\n\n}
It is important to note that while the vaccine lowers the chances of getting sick, it doesn\u2019t fully stop the bacteria from spreading (especially in people who carry it for a long time). So, while it helps reduce transmission, it doesn\u2019t completely prevent it.\u00a0<\/p>\n\n\n\n
<\/span>Types of Typhoid Vaccines<\/strong><\/span><\/h2>\n\n\n\n
There are three main types of typhoid vaccines:\u00a0<\/p>\n\n\n\n
1. Typhoid Conjugate Vaccines<\/strong><\/h3>\n\n\n\n\n
Contains a Vi polysaccharide<\/strong><\/a> (a component of Salmonella Typhi<\/em>) <\/em>linked <\/em>to a carrier protein (like tetanus toxoid<\/strong><\/a>)^{3<\/sup><\/a>.\u00a0<\/li>\n\n\n\n}
Usually given as a single intramuscular injection ^{6<\/sup><\/a>.\u00a0<\/li>\n\n\n\n}
Does not contain live bacteria.\u00a0<\/li>\n\n\n\n
Provides stronger and long-lasting immune response\u00a0<\/li>\n\n\n\n
Increasingly used in routine immunisation programs in endemic countries.\u00a0<\/li>\n<\/ul>\n\n\n\n
2. Injectable Typhoid Vaccine (Inactivated, Vi Polysaccharide Vaccine)<\/strong><\/h3>\n\n\n\n\n
Contains purified Vi antigen from Salmonella Typhi<\/em>^{5<\/sup><\/a>.<\/em>\u00a0<\/li>\n\n\n\n}
Given as a single intramuscular injection with need of subsequent booster doses.\u00a0<\/li>\n\n\n\n
Does not contain live bacteria, making it suitable for most individuals, including those with weakened immune systems.\u00a0<\/li>\n\n\n\n
While this vaccine is inactivated and safe, it is less immunogenic and does not induce long-term immune memory.\u00a0<\/li>\n<\/ul>\n\n\n\n3. Oral Typhoid Vaccine (Live Attenuated, Ty21a Vaccine)<\/strong><\/h3>\n\n\n\n\n
Contains a weakened strain of Salmonella Typhi<\/em>^{5<\/sup><\/a>.<\/em>\u00a0<\/li>\n\n\n\n}
Taken as capsules by mouth over several days^{5<\/sup><\/a>.\u00a0<\/li>\n\n\n\n}
Not suitable for children <6years, people with compromised immune systems or certain medical conditions ^{5<\/sup><\/a>.\u00a0<\/li>\n<\/ul>\n\n\n\n}
<\/span>Why is the Typhoid Vaccine Important?<\/strong><\/span><\/h2>\n\n\n\nAs of 2019, an estimated 9 million people contract typhoid each year, and approximately 110,000 die from the infection ^{1<\/sup><\/a>. The disease disproportionately affects low- and middle-income countries, where access to clean water, proper sanitation, and healthcare may be limited}^{2<\/sup><\/a>.\u00a0<\/p>}
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