PharmEasy Blog

Saline Gargle RT-PCR: The Advanced Strategy To Speed Up COVID-19 Testing

Introduction

The ICMR or Indian Council of Medical Research has recently granted permission for a COVID-19 self-sampling kit. The newly discovered method is known as Saline Gargle RT-PCR. Saline Gargle RT-PCR allows for the easy collection of samples for the COVID-19 test at home. National Environmental Engineering Research Institute, also known as NEERI scientists, developed the Saline Gargle COVID Testing method under the Council of Scientific and Industrial Research (CSIR).

It has been estimated that saline Gargle samples can generate results in just three hours! Hence, it is a patient-friendly and quick method to collect samples for the COVID-19 test at home. Since the Saline Gargle RT-PCR test requires no health professional for sample collection, it becomes easy to collect samples in rural and tribal areas. Furthermore, the Saline Gargle COVID-19 test method does not use swabs. This method is non-invasive, easy and convenient. Hence, it is more comfortable for people than nose and throat swab tests. 

The commonly used Swab test

The most common sampling method for COVID-19 is the swab test. The medical professional will extract RNA samples from the nose or throat swab sample. Then the extracted RNA sample is tested for the presence of the COVID-19 virus. The swab test method is expensive because it requires a trained medical professional to collect the swab sample, extract RNA samples for the test. In addition, the swab test requires a timeframe of four hours to generate the COVID-19 test results. Thus, the swab test method takes time.

Furthermore, the swab test uses a swab inserted into the patient’s nose or throat to collect the sample for RT-PCR. It might become uncomfortable for the patients during the collection of  samples for the COVID-19 test.  

An overview of the Saline Gargle RT-PCR COVID-19 test method

The Saline Gargle RT-PCR method uses only a saline solution-filled tube. To test oneself for the COVID-19 infection:

  1. The person is required to gargle with the saline solution for 15 seconds, rinse the mouth with the same solution for another 15 seconds and then spit it inside the tube.
  2. The sample in the tube is taken to the collection centre or laboratory. Here, it is kept at room temperature in a particular buffer solution. The unique buffer solution used is prepared by NEERI or National Environmental Engineering Research Institute.
  3. The solution is then heated and the solution produces an RNA template. The obtained RNA template is further processed for RT-PCR or Reverse Transcription-Polymerase Chain Reaction.

Hence, the Saline Gargle RT-PCR method is much less expensive and convenient than the standard nasopharyngeal (nose) and oropharyngeal (throat) swab test done at the COVID testing centres.

Saline gargle RTPCR provides more yield than swab test and is better

Dr. M.G. Kartheeka, MBBS, MD

Advantages of the Saline Test

The advantages of the Saline Gargle RT-PCR COVID Self test kit are as follows:

  1. No nose and throat swab collection The Saline Gargle RT-PCR method does not use the swab collection technique. You can do it by using only a tube filled with saline gargle solution.
  2. Cost-saving – As the saline gargle COVID testing method does not require the presence of a medical professional for sample collection, it helps save money. Furthermore, it allows people to practice self-sampling.
  3. Quick results – Recently, the testing labs were overburdened during the second wave of the novel coronavirus infection in April. But the saline gargle RT-PCR COVID testing method can save a lot of time. This method can generate COVID-19 results in just 3 hours. Hence, the Saline Gargle sampling just like the COVID self-test kit has provided momentum to COVID testing in India.
  4. There is no need for an RNA extraction kit The Saline Gargle RT-PCR method does not require an RNA extraction kit.
  5. Wider reach The Saline Gargle RT-PCR method is particularly advantageous for people living in rural areas and tribal people. This test can be done at home and does not require medical expertise.
  6. Non-invasive Nature The saline gargle RT PCR  method is not an invasive and comfortable method of sample collection.

The easier, cheaper, do it yourself test of using saline gargles for testing for covid is approved by ICMR and gives results within 3 hours.

Dr. Ashish Bajaj, M.B.B.S., M.D.

Conclusion

The Saline Gargle RT-PCR COVID testing method is productive concerning its cost. The saline gargle COVID-19 test method can prove beneficial in reducing the burden imposed on COVID Testing laboratories. This method can be very useful and desirable for people who did not have quick access to the testing centres, for example, people living in rural and tribal areas.

In addition, the Saline Gargle RT-PCR COVID testing method is also straightforward to do and does not require proper medical knowledge. In addition, the Nagpur Municipal Corporation has granted permission to NEERI to use the saline gargle RT PCR test method.

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

Covishield And Covaxin: Can The Two Vaccines Be Mixed?

Introduction 

Currently in India, the world’s largest vaccination drive is being carried out. For now, anyone above the age of 18 can be vaccinated under the programme, provided they don’t have an active COVID-19 virus or aren’t allergic to the vaccine. Even lactating mothers are eligible to get inoculated after consultation from a gynaecologist. 

Missed second dose: What happens next? 

According to current virology research, any person needs to get two vaccine dosages for a complete immunity response against the COVID-19 virus. Hence, skipping a dose is not an advisable option.  

However, what happens if a person doesn’t get the second vaccine dosage in the said time frame due to any reason?
The non-availability of the second dose will not affect the immunity received from the first dose. Although it is critical to get the second jab as soon as possible, do not skip taking it if you have surpassed the recommended timeline.

Covishield and Covaxin: Can the two be mixed?

In an interesting case in India, 20 people from Uttar Pradesh’s Siddharthnagar were given two different vaccines as their first and second dose. Their first dose was Covishield, whereas six weeks later, they were given a shot of Covaxin as their second dose.

So far, the people who were given a cocktail of these vaccines have not reported any side effects. However, the incident has begun an inquiry to study the effectiveness of administering two different vaccines on immunity.

The centre is carrying out a multitude of studies to understand whether mixing COVID-19 vaccines is possible. They have highlighted three major reasons to carry out the mixing of COVID-19 vaccines:

The ongoing debate on Covishield v/s Covaxin will soon be put to rest if a better immunity response is achieved after mixing them. Although they have entirely different mechanisms, the centre is sure that combining them will yield positive results. 

Mixing of vaccines is good as research found people produced antibody responses from all three booster vaccines, no matter which vaccine they had originally received. A booster of a different vaccine caused similar or higher antibody responses than a booster of the same vaccine

Dr. M.G. Kartheeka, MBBS, MD

What other countries are testing the feasibility of mixing two different vaccines across the world?

India is not the first country to consider ‘mixing ‘ the vaccines for further use. Several countries like the UK, USA and Spain are also testing various combinations of the vaccine.

Oxford University is conducting trials between its Oxford-Astrazeneca vaccine and Pfizer vaccine. While some people administered a cocktail of these vaccines reported mild side effects, the majority said none.

The UK, Germany and France have already given the green light for combining the two vaccines in exceptional cases, especially for older populations. More trials to understand the efficacy of the combined vaccines is still underway.

Even a study conducted in Spain, where they vaccinated people with both OxfordAstraZeneca and Pfizer’s BioNTech, reported developing a potent immune response against the COVID-19 virus.

A similar experiment is being conducted in the USA between Moderna’s and Pfizer’s COVID-19 vaccines.

Some experts have reported that combining the vaccines may be necessary if the virus mutates in the long run. Even a booster dose of a different vaccine may be essential if limited immunity has been achieved from two doses of the same vaccine.

Although studies revealed that there were higher immunogenic reactions to the booster of a vaccine than the primary vaccine, these being milder and resolved with paracetamol, this different booster elicited a better immune response and this response improves over time.

Dr. Ashish Bajaj, M.B.B.S., M.D.

Can India achieve its vaccination targets by mixing the vaccines?

The Indian Government has successfully distributed over 23 crore vaccines to all states in India. The centre is planning to procure over 75% of the vaccines directly from the manufacturers and is gearing up to provide free vaccines to everyone over 18.

Dr NK Arora (Chairman of National Technical Advisory Group on Immunisation) said that, if found effective, the mixing of both Covishield and Covaxin can boost India’s vaccine drive by several folds.

The feasibility of mixing COVID-19 vaccines could easily amplify India’s administration to 20 – 25 crores per month. It is almost a 50% boost in supply and may help achieve India’s Vaccination target.

Conclusion

The vaccines Covaxin and Covishield have been approved for people over the age of 18. However, given the large number of people residing in India, most of them concentrated in the rural regions, immunising the entire population is a mammoth task. 

While many people think that the mixing of COVID-19 vaccines may help to make up for the vaccination shortage in India, but it is important to understand that it will require thorough testing and research to ensure its safety and effectiveness. As per the current studies and advisories, it is not allowed to mix two doses of different vaccines. You have to take the second dose of the same vaccine you took your first jab with.

The Head of India’s COVID-19 Taskforce, VK Paul, in an interview, has said that it is ”scientifically and theoretically” possible to mix the two vaccines. However, it will require “robust scientific evidence” to be carried out.

Without appropriate evidence, mixing two vaccines may prove to be more lethal than useful and endanger the lives of thousands of people. But, if it is found to be successful and safe, the centre will implement it in the near future.

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

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Lockdown Is Easing, But Is Your Body Prepared? Let’s Find Out

Since the beginning of 2020, many of us have been scouring through the internet for tips on how to increase immunity. With the massive death rate of the second wave of COVID-19 in 2021, we have become all the more cautious and concerned about personal health. This is because boosting our immune system is still considered one of the most effective ways to prevent contracting COVID-19. 

While doctors and other medical health workers have been actively educating the masses on how to boost immunity, the mutating nature of the virus adds a lot of ambiguity. Therefore, despite the vaccinations, we should not stop following COVID protocols.

Now that lockdowns are easing and we may be going out, it is important to understand if we have good immunity against the virus. Here are a few things that can be helpful.

Check if you have developed Antibodies against COVID

Not sure if you had COVID or had come in close contact with a COVID patient and did not develop COVID symptoms? Or you have recovered from COVID, then test yourself for IgG COVID antibodies. This test tells you that you have been infected with COVID in the past and now you have developed antibodies. 

Got vaccinated? Test your antibodies!

The vaccines developed for COVID-19 have till now proven to be about 90% effective against the deadly disease. Moreover, this 90% protection is only guaranteed after the second dose of vaccination. People who have been vaccinated can undergo the COVID Spike S1 Antibody Test. This can give an idea of if antibodies have developed and how many. Such antibodies reduce the probability of getting the infection or manage the severity of it. 

To better understand the health of our immune system, we can undergo other simple diagnostic tests as well.

Damaging Effects of COVID Medication

People undergoing COVID treatment are prescribed heavy doses of medication that can often be harmful to the kidney and liver. Therefore, taking a Kidney Function Test (KFT) and a Liver Function Test (LFT) is beneficial to understand the status of your kidney before stepping outside.

Vitamin Deficiency

Quite a lot of us are now working from home and rarely get a healthy exposure to sunlight. This can result in vitamin D deficiency that can prove detrimental to our immune system. To identify the extent of deficiency, it is advisable to take tests that also identify the levels of Vitamin C, D and B12 in our body. Comprehensive tests that include the aforementioned, as well as Complete Blood Count (CBC) and Haemoglobin count, can also give us a good idea about our level of immunity.

Also Read: Sepsis: A Guide to Understanding Its Symptoms, Causes, and Treatment

Season Change May Bring Additional Challenges

With the arrival of the monsoon, many of us are even more prone to contracting infectious diseases like the flu and the common cold. To understand how to make the immunity system stronger during such times of season change, it is better to first get an idea of your current health status.

Also Read: Benefits of Cloves Sexually: Exploring Evidence-Based Enhancements

Conclusion

When looking for ways and means on how to increase immunity, it is important to know the current status of our immune system. This is because to boost our immunity we need to first know where we stand and only then can we set our health goals right. Therefore, by standing together as a community that is well-informed about personal health, we can overcome this pandemic. Also, with the help of diagnostic insights about our personal health, India can fight COVID-19 successfully.

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

Avail COVID Tests At Home Through PharmEasy!

With the second wave of COVID being much more contagious than the first wave, the need for testing has sky-rocketed because so many people are contracting the disease. Even if you are following all the safety measures, you should familiarize yourself with the different types of  COVID test, their purposes, when they are necessary and how you can book such tests. In the time of emergency, the sooner you act, the more quickly you or your loved one will receive the medical care needed.

PharmEasy, India’s beloved and trusted online healthcare platform has jumped in at this time of crisis to help people in all possible ways, from safely delivering medicines at the doorstep, organizing vaccination drives to making the COVID test easily available. Read on to find out which tests can be booked on PharmEasy. This COVID test at home is made possible through the home collection of samples.

RT-PCR

This test detects the presence of coronavirus RNA in the mucosal lining of your nose or throat. You can opt for this test the moment you notice the symptoms of COVID, such as fever, sore throat, body ache or headache, diarrhoea, nausea, conjunctivitis or loss of taste and smell.

You can book a test by filling out this form and you can also share it with your acquaintances who might need it in the future. 

Tests for when you have been diagnosed with COVID

After the diagnosis of COVID, it is essential to monitor the patient because COVID can have many consequences on the person’s health. For this reason, PharmEasy has made provisions for the following tests for COVID patients:

This test detects the level of C-reactive proteins (produced by the liver) to determine how effectively the liver is functioning post injury or infection.

Lactate dehydrogenase is an essential enzyme that helps the body produce energy from glucose. It is formed in the cells of the body. But if the tissues of the body are damaged, then traces of lactate dehydrogenase can be found in the blood. This test can find LDH in blood.

Ferritin stores iron and is present in all our cells. This test can tell you if your ferritin levels are below normal which would indicate that your body is unable to store adequate iron in its cells. 

Test after vaccination

The goal of the COVID vaccine is to induce immunity against COVID by generating antibodies in your blood. The COVID Spike S1 Antibody test can help determine how strong your immunogenic response is by checking for the presence of COVID S1 spike protein antibodies. 

Test to find out if you contracted Asymptomatic COVID

The Advanced Full Body Check-Up with COVID Antibody test is a comprehensive test that will check multiple parameters including the presence of COVID antibodies, lipid profile, liver function, thyroid profile, etc (66 parameters altogether).  

You can book any of these tests through the PhamEasy app or by calling us directly. Share the information with your friends and family. Stay home, maintain the COVID safety protocol and get vaccinated as soon as you can. 

Disclaimer: The above information has been prepared by a qualified medical professional and may not represent the practices followed universally. The suggestions listed in this article constitute relatively common advice given to patients and since every patient is different, you are advised to consult your physician, if in doubt, before acting upon this information. Lupin Limited has only facilitated the distribution of this information to you in the interest of patient education and welfare.

New COVID-19 RT-PCR Test Kit ‘ViraGen’ By Cipla In Partnership With Ubio Biotech Available Now

Introduction

With Cipla’s continuous efforts in ensuring treatments to detect and challenge this COVID-19 pandemic, the new COVID-19 RT-PCR test kit ‘ViraGen’ by Cipla has been launched and is now available in the market. The drug major partnered with Ubio Biotechnology Systems for the development of this New ViraGen test kit. As per Cipla’s regulatory filing, this launch of the ViraGen COVID-19 test will aid in addressing the ongoing testing and diagnosis issues in COVID-19 due to capacity while moving forward with the company’s expansion in the diagnostic field.  

This New COVID-19 RT-PCR test will be very fruitful to boost up the COVID-19 diagnosis. ViraGen Cipla test kit has concluded the lagging demand of diagnostic kit and hence the management of COVID-19. ViraGen COVID-19 test kit is Cipla’s third effort towards COVID-19 testing.

How does the ViraGen COVID-19 Test work? 

ViraGen COVID-19 test is Cipla’s latest offering towards COVID-19 management and care. ViraGen Cipla test kit has received approval from the Indian Council of Medical Research (ICMR) as a diagnostic kit for COVID-19. ViraGen Cipla test kit is a real-time detection kit. It is based upon the multiplex Polymerase Chain Reaction (PCR) technology.  

ViraGen assists in the diagnosis and detection of the SARS-CoV-2 N gene and the ORF lab gene. It provides specificity of 98.8% and a sensitivity of 98.6% when compared with the ICMR standard tests. ViraGen Cipla test kit performs qualitative detection. ViraGen COVID-19 test kit detects the nucleic acid from SARS-CoV-2, both in the lower and the upper respiratory specimens from individuals who have symptoms of COVID-19.

ViraGen and COVID-19 in India 

With the COVID-19 infection being widespread, there is always a need for diagnostic kits which can detect the virus at the initial stages and help in controlling further expansion. There has been antigen testing and RT-PCR testing being extensively used to track down and break the chain of coronavirus infection. Cipla has already partnered for antigen and antibody detection kits. This New COVID-19 RT-PCR test kit is now easily accessible from the market. The ViraGen COVID test kit is one step forward towards this motive by Cipla. Cipla has also taken various other efforts towards the ongoing COVID-19 pandemic in the past.

Why the ViraGen COVID-19 test? 

At present, the real-time PCR test is the uttermost reliable, accurate and preferred method for the detection of COVID-19 in symptoms. ViraGen COVID-19 test being the real-time detection kit provides the highest accuracy and diagnosis if there is the existence of coronavirus in your system. The test involves sampling on a nasal swab or a throat swab that is sent to a laboratory to be analysed for further diagnosis. The RT-PCR test continues to be the ”gold standard” for diagnosing COVID-19.

India, being one of the most populated countries, turned into a COVID-19 warplace. The need for diagnosis of COVID-19 before one individual infects another individual is crucial. The New ViraGen test kit was the need of the hour. This New COVID-19 RT-PCR test kit will help manage the volume. A densely populated country like India will benefit from the ViraGen Cipla test kit. Cipla has used its market distributors to make sure that ViraGen is available in the market from May 25, 2021.

Conclusion

In case one shows symptoms of COVID-19 infection like high fever, dry cough, loss of smell or taste, sore throat or breathing issue, it would be smart to choose the New ViraGen test kit to have accurate results. Even if one may have been in contact with any individual who has tested positive, they should undergo COVID-19 testing.

In case you are diagnosed positive of COVID-19, isolate yourself to protect the ones you love and stop the infection chain. Keep a thermometer and oximeter handy and maintain track of your temperature and oxygen levels. Contact your healthcare provider immediately and take the medications as per their suggestion. Also, do not stop taking the precautionary measures of covering your face and mouth and regular sanitisation of hands to control the spread of the virus.

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

ICMR Guidelines | COVID-19 Home Testing Kits Approved

Introduction

Recently there has been another medical breakthrough in the fight against COVID-19. The Indian Council of Medical Research (ICMR) has approved a home Rapid Antigen testing (RAT) kit for COVID-19. According to the ICMR, the COVID-19 home test kit manufactured by Mylab Discovery Solutions Ltd, Pune, has been validated and approved. The ICMR has clearly stated that since the COVID-19 home test is a nasal swab test it should be conducted as per the instructions given by the manufacturer in the user manual.

How does the COVID-19 home test work?

The COVID-19 RAT test enables people to collect their nasal sample and test if they are COVID-19 positive. With the pandemic spreading like wildfire in many states of India, there is immense pressure on diagnostic labs conducting RT-PCR tests. Moreover, the RT-PCR test takes two to three days to give results which delay the start of treatment for positive patients. The ICMR has now approved the COVID-19 home test kit as it gives quick results in fifteen minutes. The guidelines that need to be followed while conducting the COVID-19 RAT test are given below.

COVID-19 home test guidelines:

COVID-19 home test – Do’s and Don’ts

Tracking cases across India

The company manufacturing the COVID-19 home test kits promises to make millions of kits for India and that too at an inexpensive price. India has a huge population and regular testing through RT-PCR is not only impossible but also expensive. As a result, many avoid getting tested despite having symptoms. The self-testing kit being cheaper is accessible to a huge portion of the population who earlier refrained from getting tested.

The person using the COVID-19 home test kit must download MyLab’s AI-powered mobile app to get their reports as soon as possible. The home testing mobile app is available in the Google Play store and Apple store and must be downloaded by all users. The mobile app submits the result to ICMR immediately so that patients can get their reports and start treatment if found COVID-19 positive.

The mobile app is a comprehensive guide of the testing procedure and will provide a positive or negative test result to the patient. All users ‘MUST’ click a picture of the test strip after completing the test procedure with the same mobile phone which has been used for downloading the mobile app and user registration.

Conclusion

The home RAT test for COVID-19 is a significant step in our fight against COVID-19. Although less sensitive, it gives patients a sense of direction to start isolation and treatment as soon as found positive. Rapid antigen tests are also cheaper compared to RT-PCR and reduce the excessive pressure and the dependence on RT-PCR tests. But you should consciously follow the instructions given by both ICMR and the home testing kit company before conducting the test at home.

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

New Anti-COVID-19 Medicines In India

In light of the growing death toll and India battling against the second wave of COVID-19, the Govt. of India recently granted permission for emergency use of two anti-COVID 19 medicines, namely-,   2-DG by the Defence Research and Development Organisation (DRDO), in collaboration with Dr. Reddy’s Laboratories (DRL), Hyderabad, and Antibody Cocktail (Casirivimab and Imdevimab) by Roche India with Cipla Limited as a distribution partner.   2-deoxy-D-glucose, abbreviated to 2-DG, is an oral, therapeutic medicine and an antibody cocktail available in injectable form.  

2-DG is permitted by the Drugs Controller General of India(DCGI) for emergency use and as an adjunct remedy in moderate to severe COVID-19 patients. In contrast, the Central Drugs Standards Control Organisation (CDSCO) approved the antibody cocktail to treat confirmed cases of mild to moderate COVID-19 patients over 12 years of age at an increased risk of developing severe COVID-19 disease.

2DG as a Medicine

2DG is an oral medicine available on the doctor’s prescription only to hospitalized patients due to moderate to severe COVID-19. It is to be used as adjunct (add-on) therapy in addition to the current standard protocol.

The 2-DG comes in a sachet in the form of oral powder and can be consumed by dissolving in water. The dose and duration of this medicine will be determined by your treating doctor.

Origin of anti-COVID Remedies

The 2-DG is an anti-COVID-19 medicine developed domestically. However, Roche will import the antibody cocktail, which will be made available in India with a contract with Cipla Ltd.

The 2-DG has been developed by the DRDO’s laboratory Institute of Nuclear Medicine and Allied Sciences, in alliance with Hyderabad-based pharma company Dr. Reddy’s Laboratories. It has gone through extensive clinical trials and was approved for emergency use following a green signal from the head of the apex body, the Drugs Controller General of India, on 1 May 2021.

Roche India has been given the Emergency Use Authorisation (EUA) for COVID-19 antibody-drug cocktails, Casirivimab and Imdevimab, to treat COVID-19 patients in India.

How do anti-COVID-19 remedies work?

The therapeutic anti-COVID-19 medicine 2-DG is a glucose analog or pseudo glucose. Any virus requires glucose for its growth and multiplication. It works by entering or accumulating into infected cells upon ingestion and preventing virus growth by blocking viral synthesis, multiplication, and energy production. Its accumulation, specifically in the virus-infected cells, makes its mechanism unique. This medicine is expected to save lives by its distinct action against coronavirus, which may also reduce the hospital stay of COVID-19 patients.  The Casirivimab–Imdevimab Antibody cocktail injection is a combination of two monoclonal antibodies. Monoclonal antibodies are laboratory-made proteins that mimic the action of immune cells and fight off pathogens such as viruses.  It works by blocking the attachment and entry of viruses into human cells and hence prevents the spread of infection

The antibody cocktail can be acquired by a doctor’s prescription only and should be administered in settings where healthcare providers have instant access to allergic reaction treatment, such as those used for anaphylactic shock.

The antibody cocktail jab effectively treats mild-to-moderate COVID-19 symptoms in children aged 12 years or older and weighing no less than 40 kg and adults. It especially treats those at high risk of getting a severe COVID-19 infection but may not need oxygen.

The cocktail drug can help high-risk patients before their condition worsens, reducing hospitalization risk and mortality rates by 70%. Further, it shortens the length of symptoms by about four days.

The intravenous (IV) administration takes about 20 to 30 minutes. Subcutaneously, four syringes of 2.5 ml (2 each of Casirivimab and Imdevimab) must be administered simultaneously at four different locations on the stomach or thigh.

Efficacy of anti-COVID remedies

The 2-DG drug trials carried out in over 110 patients in Phase- II and Phase- III clinical trials were conducted on 220 patients between December 2020 to March 2021 at 27 COVID hospitals in Delhi, Uttar Pradesh, West Bengal, Gujarat, Rajasthan, Maharashtra, Andhra Pradesh, Telangana, Karnataka, and Tamil Nadu.  

The cocktail trial conclusions are derived from Regeneron’s Phase 3 clinical trial, which is the foremost clinical trial to date that assessed COVID-19 treatment in patients who have COVID-19 but are not hospitalized. The trial included 4,567 patients who recently developed COVID-19 and were at high risk for a severe form of ailment. The 2,400-mg dose cut the hospitalization risk and death by 71%.

Conclusion

It is important to note that DRDO’s anti-COVID-19 medicine 2-DG  is an adjunct therapy and not a substitute for standard treatment. The drug pricing of 2-DG is yet to be determined based on its affordability, and the first 10,000 doses will be rolled out for public use this week. These doses have been recommended for use in moderate-to-severe COVID-19 cases only. 

The launching of this medicine amidst an ongoing battle between the country and the distressing second wave of the pandemic has been a sign of hope for many because it resolves the struggle for hospital-grade oxygen and hospital beds.

In this situation, 2-DG accelerates the recovery rate and decreases oxygen dependence, leaving the beds available for those patients who require critical care. We believe it is fair to put our faith in this medicine for all the right reasons mentioned above. Plus, it does not hurt that there will not be a needle involved in this procedure!

The medicine has been launched while the country battles the distressing second wave of the pandemic that has triggered a struggle for hospital-grade oxygen and hospital beds. In this situation, 2-DG accelerates the recovery rate and decreases oxygen dependence, leaving the beds available for those patients who require critical care. The antibody cocktail was administered to former US President Donald Trump after he was diagnosed with COVID-19.

Disclaimer: The information included on this site is for educational purposes only and is not intended to be a substitute for medical treatment by a healthcare professional. Because of unique individual needs, the reader should consult their physician to determine the appropriateness of the information for the reader’s situation.

Daily New COVID-19 Cases Less Than Three Lakhs After A Month In India

Introduction

In the year 2020, the whole world witnessed the onslaught of the deadly Covid-19. The first Covid-19 case was reported in Wuhan, China, in December 2019. This virus soon made its way around the world and by January 2020, countries such as India, Russia and the United Kingdom had begun fighting this coronavirus.  

On July 17th 2020, India saw the highest death count so far which was around 2000 deaths a day. Wearing a mask, imposing lockdowns and curfews helped to reduce the spread of the virus. However, about seven months after the first wave, India experienced the second wave of Covid-19.

Second Wave of Covid-19

The Covid-19 cases started to increase rapidly from March 2021. India recorded the lowest number of new cases in that month on April 22nd, with around three lakh cases per day. On May 6th, 2021, India registered 4,14,188 new cases, the highest number of cases ever recorded. From May 9th onwards, India started seeing a steady decline in Covid-19 cases across the country. Due to government impositions and people’s vigilance, India slowly and steadily is recovering from Covid-19.

With the help of medical facilities and doctors, vaccines for this deadly virus were developed. To date, India has administered 187 million doses of the Covid-19 vaccine. So far, 3.1% of the total population of India, that is, 41,686,052 citizens, have been fully vaccinated. 

Safe and effective vaccines help ensure that COVID-19 does not result in severe disease and death, especially in vulnerable populations like children and the elderly. Vaccination protects against COVID-19 and reduces the likelihood of new variants from emerging.

Dr. Ashish Bajaj – M.B.B.S, M.D.

Covid-19 in India 

In the initial days of the pandemic, the spread of the Covid-19 virus in India was low. But due its high transmissibility, it spread like wildfire, infecting millions of people in the country. Because the outbreak of Covid-19 in India was an unexpected and unfortunate occurrence, India was unprepared. Every individual was affected by the ongoing pandemic.  

In India, Covid-19 has had a major impact on the following: 

From the smallest state to the largest, all the states of India are still fighting against Covid-19. The worst affected states include Tamil Nadu with 1,842,344 active cases, Maharashtra with 5,579,897 active cases and Karnataka with 2,424,904 active cases and Kerala with 2,347,966 active cases.  

Covid-19, termed SARS (Severe Acute Respiratory Syndrome), affects a person’s lungs and respiratory system. In the first wave of Covid-19, the country was able to manage with its existing supply of oxygen and oxygen concentrators. However, when the second wave of Covid-19 came out of nowhere, the number of infected people skyrocketed, resulting in a surge in demand for medical equipment such as ventilators, oxygen cylinders and ICU beds. At that point, India was not prepared and could not keep up with the rising cases, which led to the collapse of medical facilities.  

India was faced with a shortage of the most basic medical facilities. With the help of medical aid, doctors and frontline workers, the government arranged oxygen cylinders and concentrators. Many other countries like Russia, UK and Malaysia helped India during the crisis by supplying oxygen and ventilators by air. So far, 11,058 oxygen concentrators, 13,496 oxygen cylinders and 19 oxygen generation plants have been set up to overcome the oxygen crisis in India.  

About 7,365 ventilators and five lakhs vials of life-saving medicines are being made to meet demand and are supplied to patients or hospitals by air or roadways as early as possible.    

India on the road to recovery

Though the second wave of Covid-19 was unpredictable, India was aware of how to combat the situation. Imposition of lockdowns and curfews proved to be effective in curbing the spread of  Covid-19. After three months of the arrival of the second wave of Covid-19, India’s recovery is visible and gradual. The National Recovery Rate has increased to 87.76% from 81. 77%. Vaccination administered in India exceeded 20 cores under Phase 3 of the vaccination drive in the country. To date, around 10 million healthcare and frontline workers working as warriors against Covid-19 have been vaccinated. For over a week consecutively, more than 20 lakhs tests have been conducted in India. 

As active cases are gradually decreasing, the recovery rate is increasing, which means reduced death tolls. States like Maharashtra, Karnataka, Kerala, Uttar Pradesh and Rajasthan are the fastest recovering states. Restrictions have also been normalized to some extent. Restaurants, malls and offices are slowly being reopened with some restrictions. 

The March Ahead 

Though there is a decline in the number of active Covid-19 cases in India, the pandemic is still not over; not until 244 districts with more than 20% positivity rate and 479 districts crossing the 10% positivity rate meet WHO’s standard of 5% positivity rate. This can only happen when everyone strictly abides by the Covid-19 guidelines and gets vaccinated.

Testing plays a vital role in reducing the spread of Covid-19. The Indian Council Medical Research, with the help of hospitals and doctors, is trying to increase testing procedures in the remotest parts of India. There is more need for testing kits for districts with a 10% or higher positivity rate.

Conclusion

Scientists are now speculating that the third wave of Covid-19 will hit India by October 2021. India is learning from the second wave and is preparing itself so that conditions do not get out of hand. Union Health Minister Harsh Vardhan stated, “India would have procured 267 cores of Covid-19 vaccination doses by the end of 2021”. 

The government and doctors are trying their best to combat the situation. Still, as individuals, it is our duty to maintain social distance, wear a mask, and get tested if we experience any Covid-19 symptoms. It is also important to try to get vaccinated as early as possible. 

How to treat Covid-19 at home? 

If symptoms become severe, it’s better to get treated by doctors as soon as possible.  

Is the Covid-19 test painful? 

When will the Covid-19 pandemic end in India? 

To know about the Covid-19 live update visit – https://www.mohfw.gov.in/

Disclaimer: The information included at the site is for educational purposes only and is not intended to be a substitute for medical treatment by a healthcare professional. Because of unique individual needs, the reader should consult their physician to determine the appropriateness of the information for the reader’s situation. 

Has Your Child Tested Positive For COVID? Here’s What To Do

The second wave of coronavirus in India is much stronger than the first one, leading to widespread concern. The extent of the spread of COVID is no longer limited to a certain age group, affecting children and adults alike. While there are cases throughout the country, cities such as Mumbai alone have seen a 65% increase in COVID-19 positive reports in paediatric cases since the beginning of March.

This may sound like an alarm bell, but as per the data and research, most cases with children are mild when compared to others. They generally have better prognosis, milder symptoms and are asymptomatic. The major COVID-19 symptoms seen in children are: 

As a parent, it is natural to seek answers regarding the steps you need to take if your child has tested COVID positive. It is necessary to understand that the impact of the disease is low in most cases of COVID in children and it is crucial not to panic. While doing your best to stay calm, follow medical guidelines, safety protocols and your doctor’s advice for a smooth recovery. 

if your child gets COVID-19 they should stay quarantined at home for 10 days after positive testing or onset of symptoms, and must demonstrate improving symptoms without fever for 24 hours.

Dr. M.G. Kartheeka, MBBS, MD

When Should You Take Your Child to the Doctor?

If your child needs to be tested, it is recommended that you observe and keep a close watch on the developing symptoms of COVID-19. The immediate step to be taken is to ensure safety protocols, such as wearing a mask, sanitising and physical distancing, are followed within the family. Consult your child’s doctor for further assistance.

Children with mild symptoms can stay at home throughout their recovery without the need for hospitalisation, if suggested by a pediatrician. However, if your child is experiencing serious symptoms that persist for more than 7 days, medical attention is necessary. The symptoms may include:

What If Your Child Tests Positive for COVID-19?

The spread of coronavirus is mainly from person to person. Parents need not fear, as based on current evidence, children do not appear to be at a higher risk. 

Parents can help prevent the spread of germs and educate their children about how to stop the spread of COVID-19 infection. Besides encouraging your child to follow safety protocols and hygienic methods, do the following: 

Make sure you consult your doctor in any type of medical emergency. It is advised not to self-medicate your child. A proper diagnosis of the symptoms by a paediatrician is required for any prescription or medication.

What is the COVID-19 Incubation Period for Children?

The incubation period is defined as a period between the contraction of the virus and the onset of symptoms. In the case of the coronavirus,

On average, symptoms showed around 5 days post-exposure to the virus. While caring for your children, keep in mind that the contagious stage is around 1-2 days before the symptoms occur. Hence, regardless of the stage, it is advised that you follow safety protocols strictly throughout the period of disease and recovery. 

Will There be a COVID-19 Vaccine for Children?

Vaccines go under several clinical trials so that their safety and effectiveness is ensured; hence their availability depends on these trials. For now, the best way to protect and recover from COVID-19 is by following public safety and health guidelines. 

Educate Your Kids Now, for a Safer Tomorrow

As a parent, explain the importance of hygienic practices and safety protocols and their role in disease prevention. It is natural to have queries, but the key is to refrain from panicking and educating your children instead. If a child tests positive for the virus, ensure that you put safety and hygiene, along with mental health.

The question of mental health arises as children can commonly have misconceptions or queries about the disease. As parents, do your best to have an age-appropriate conversation where you explain the situation in a manner that induces a sense of calm and answers their questions as well. Lead by example, tell them about safety and hygiene and teach them the appropriate measures to be taken during outbreaks and related health issues. 

Do consult a paediatrician at the earliest even for the mild and asymptomatic cases. Monitor your child’s health and behaviour and watch out for signs and symptoms requiring medical attention. 

To relieve stress, family time with safety protocols is recommended. Focus on the things to be grateful for while spending quality time. Along with these, ensure that your kids constantly wash their hands, sanitise, maintain respiratory hygiene, adhere to proper disposal of materials, etc. 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

The List Of Walk-In COVID Sample Collection Centres In Mumbai And Delhi That You’ve Been Looking For!

We are in the midst of the second wave of COVID-19 and thousands of people are getting infected every day. Naturally, people are worried and stressed. In this circumstance, here’s something for Mumbaikers and Delhiites to help prepare for and deal with a COVID-19 infection in the family. The first thing you need to know is where you can get tested if you suspect that you or someone you know is experiencing COVID-19 symptoms. That is why we have put together a list of centres where you can walk in and get tested for COVID-19.

COVID-19 RT-PCR walk-in testing centres in Mumbai

These centres are operating every day of the week and anyone can come in to get tested for COVID-19 for Rs.600 and get a report within 36 hours. No prior registration is required. Here are all the details –

CentreAddressCollection hoursMaps Location
Nilkanth Medicos, Malad EastShop No. B-1, Sunshine CHS, Subhash Lane, CTS 416, Near Vaishno Devi Mandir, Malad East, Mumbai 400097Monday – Sunday: 10 AM – 6 PMhttps://g.page/nilkanth-medico?share
Treebo Trend Olive Inn, KurlaFortune Arcade, Near EQUINOX Business Park / Bus depot CST, No. 27-A, Lal Bahadur Shastri Rd, Kurla West, Mumbai, Maharashtra 400070Monday – Sunday: 9 AM – 3:30 PMhttps://goo.gl/maps/ood8ZyBcgBLxJP8K7
Treebo Trend Amber International, Andheri EastS11 JN Marshall Building Near Akruti Orchid Park, Saki Naka, Andheri East, Mumbai, Maharashtra 400072Monday – Sunday: 9 AM – 3:30 PMhttps://goo.gl/maps/6gRyms5mFvWf53Zz8
Treebo Trend Shri Krishna Paradise, AiroliNo.X-1/2, Near Vitava , T.T.C. Industrial Area, Ganpati Pada Near Vitava Kalwa, Octroi Naka, Thane – Belapur Rd, Navi Mumbai, Maharashtra 400605Monday – Sunday: 9 AM – 3:30 PMhttps://g.page/srikrishna-paradise-hotel?share

COVID-19 RT-PCR walk-in testing centres in Delhi

These centres are operating every day of the week and anyone can come in to take the COVID-19 RT-PCR test for Rs.800 only and get a report of the same within 36 to 48 hours. No prior registration is required. Here are all the details –

CentreAddressCollection hoursMaps Location
Treebo Trend Natraj Yes Please, Paharganj1750, Chuna Mandi, Opposite Imperial Cinema, Pahar Ganj, Delhi 110055, New Delhi, Delhi – 110055Mon- Sun 12 PM – 6 PMhttps://goo.gl/maps/JhrpRARrWaEmGrEN9
Treebo Trend Nysha Palace, MahipalpurA206 / B, Road No. 4, Lane No.9, Mahipalpur, Delhi – 110037Mon- Sun 12 PM – 6 PMhttps://goo.gl/maps/PtSVAJ6k4EbooJqq7

Why should you save this list of walk-in centres?

Share this with your friends and relatives now! Anyone in need can go through this vital information and get tested without any hassle.

What is the COVID-19 RT-PCR test?

Reverse transcription-polymerase chain reaction (RT-PCR) test can detect coronavirus viral RNA in our mucus membrane. When the coronavirus enters the body, it leaves traces of its RNA in the mucus of the nose and throat. Samples of this mucus are collected and analysed to see if the person has COVID-19.

When should you get the COVID-19 RT-PCR test done?

COVID-19 RT-PCR test is recommended when a person experiences the symptoms of COVID-19. New and old symptoms include –

Speak with your doctor and act according to his/her instructions.

If the person suspected to have contracted COVID-19 is feeling too unwell or weak, you can book a home sample collection. Click here to get your online booking form for getting tested in Mumbai.  

Stay home to stay safe. Wear double masks when you have to go out, use your hand sanitiser frequently and maintain social distancing. Follow the COVID-19 protocol and save this information in case you or your loved ones need it.  

Keep your health in your own hands.

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

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